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目的评价婴幼儿尿石症及DNA氧化损伤是否与三聚氰胺污染的婴幼儿配方奶粉(MCPF)喂养与有关。方法根据不同喂养方式将婴幼儿分为四组:(1)MCPF摄入量超过90%的婴幼儿组,(2)MCPF摄入量介于50%~90%之间的婴幼儿组(3)MCPF摄入量<50%的婴幼儿组,(4)摄入奶粉90%以上为不含三聚氰胺的进口配方奶的婴幼儿组。组1~组3为观察组,组4为对照组。并采用“病例-对照”方法评价各组婴幼儿患尿石症的情况及尿中8-羟基脱氧尿苷(8-OHdG)的水平。结果 MCPF的摄入量与尿石症显著相关。四组尿液样本每摩尔肌酐中8-OHdG含量的平均值分别为:(2.03±0.52)μmol、(1.67±0.28)μmol、(1.90±0.39)μmol、(1.85±0.47)μmol。结论实验数据显示三聚氰胺可导致尿石症,但未造成婴幼儿DNA氧化损伤水平的显著上升。
Objective To evaluate whether infantile urolithiasis and DNA oxidative damage are associated with melamine-contaminated infant formula (MCPF) feeding. Methods The infants were divided into four groups according to different feeding methods: (1) infants and young children with MCPF intake above 90%, (2) infants and young children with MCPF intake between 50% and 90% (3 ) Infants and toddlers with <50% MCPF intakes, and (4) more than 90% of infants entering the formula without melamine. Group 1 ~ group 3 for the observation group, group 4 for the control group. Urinary stone urolithiasis and urinary 8-hydroxydeoxyuridine (8-OHdG) levels were evaluated using the “case-control” method. Results The intake of MCPF was significantly associated with urolithiasis. The mean values of 8-OHdG per 1 mol creatinine were (2.03 ± 0.52) μmol, (1.67 ± 0.28) μmol, (1.90 ± 0.39) μmol and (1.85 ± 0.47) μmol respectively in the four urine samples. Conclusion Experimental data show that melamine can cause urolithiasis, but did not cause a significant increase in DNA oxidative damage in infants and young children.