Klemperer1942年首先发现,当时命名“胶原病”。这类病的结缔组织均有粘液样水肿,纤维蛋白变性以及坏死性血管炎的基本病变,故现在称之为结缔组织病。结缔组织病在耳鼻喉科的症状是全身疾病的一部分,在耳鼻喉科临床常见的有: 1 Wegener肉芽肿 1936年Wegener首先报道,其是一种特殊类型的坏死性肉芽肿性血管炎,主要累及呼吸道、肾脏、皮肤等脏器而产生相应严重的临床表现。 Klemperer first discovered in 1942, was named “collagen disease.” These diseases of connective tissue are mucoid edema, fibrin degeneration and necrotizing vasculitis, the basic lesion, it is now called connective tissue disease. Symptoms of connective tissue disease in otolaryngology are part of a generalized disease and are clinically common in otolaryngology: 1 Wegener’s granuloma First reported by Wegener in 1936 as a special type of necrotizing granulomatous vasculitis, mainly Involved in the respiratory tract, kidneys, skin and other organs and produce the corresponding serious clinical manifestations.