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目的:回顾性分析妊娠期肝内胆汁淤积症(ICP)患者胎儿窘迫发生的原因及孕妇血胆汁酸浓度与胎儿窘迫发生率的关系。方法:选择2005年1月~2012年12月海宁市妇幼保健院收治的335例ICP患者,比较孕妇合并胎儿窘迫组与未发生胎儿窘迫组的孕周、孕妇体内血总胆汁酸值、孕妇处理及妊娠结局。结果:335例ICP孕妇分娩双胎12例,共分娩新生儿347例,剖宫产272例患者中发生胎儿窘迫116例,死胎1例,未发生胎儿窘迫218例。结论:当胆汁酸值≥30μmol/L时,胎儿窘迫发生率增加明显。
Objective: To retrospectively analyze the causes of fetal distress in patients with intrahepatic cholestasis of pregnancy (ICP) and the relationship between serum bile acid level and the incidence of fetal distress in pregnant women. Methods: From January 2005 to December 2012, 335 cases of ICP patients were treated in Haining Maternal and Child Health Hospital. The levels of blood total bile acid and gestational age in pregnant women with fetal distress and those without fetal distress were compared. And pregnancy outcome. Results: 335 cases of ICP pregnant women delivered twins in 12 cases, a total of 347 cases of neonatal birth, fetal distress in 272 cases of cesarean section occurred in 116 cases, 1 case of stillbirth, without fetal distress in 218 cases. Conclusion: When the bile acid value ≥ 30μmol / L, the incidence of fetal distress increased significantly.