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目的：探讨预防川崎病的冠状动脉并发症采用静脉注射免疫球蛋白（ＩＶＩＧ）的疗效。方法：川崎病５０例分为３组。ＩＶＩＧ组１７例（男性１１例，女性６例；年龄３．３±１．１ａ）给免疫球蛋白（ＩＧ）２００～２５０ｍｇ／（ｋｇ·ｄ），ｉｖ×４ｄ；肌内注射ＩＧ（ＩＭＩＧ）组１５例（男性１０例，女性５例；年龄２．５±１．１ａ）给ＩＧ２０～３０ｍｇ／（ｋｇ·ｄ），ｉｍ×７ｄ；单用阿司匹林对照组１８例（男性１１例，女性７例；年龄２．５±１．５ａ）；上述３组在发热期均给阿司匹林５０～８０ｍｇ／（ｋｇ·ｄ）分３～４次ｐｏ，热退后减量为５～１０ｍｇ／（ｋｇ·ｄ）×６～１０ｗｋ。结果：总热程ＩＶＩＧ组显著短于对照组（Ｐ＜０．０１），ＩＭＩＧ组与对照组无显著差异；冠状动脉异常率：ＩＶＩＧ组６％，ＩＭＩＧ组２７％及对照组３３％。结论：ＩＶＩＧ组预防川崎病疗效好，剂量适当
Objective: To investigate the efficacy of intravenous immunoglobulin (IVIG) in preventing coronary artery complications of Kawasaki disease. Methods: Kawasaki disease 50 cases were divided into 3 groups. Immuno-globulin (IG) 200 ~ 250mg / (kg · d) and iv × 4d were administered intramuscularly (IGIG) in 17 IVIG patients (11 males and 6 females; age 3.3 ± 1.1a) 15 patients (10 males and 5 females; age 2.5 ± 1.1a) were given IG20 ~ 30mg / (kg · d) and im × 7d; 18 patients (11 males and 7 females) were treated with aspirin alone (Age 2.5 ± 1.5a). The above three groups were given aspirin 50 ~ 80mg / (kg · d) for 3 to 4 times po in the fever period, and the dosage was 5 ~ 10mg / (kg · d) × 6 ~ 10wk. Results: Total heat stroke in IVIG group was significantly shorter than that in control group (P <0.01). There was no significant difference between IMIG group and control group. Coronary artery abnormalities rate was 6% in IVIG group, 27% in IMIG group and 33% in control group. Conclusion: The prevention of Kawasaki disease in IVIG group is effective and appropriate dose