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从感染 NK65株柏氏疟原虫的斯氏按蚊涎腺提取子孢子,用高浓度氯喹(0.8mg/ml)体外培育或γ射线照射减毒后,与感染性子孢子的免疫原性进行比较。感染性子孢子免疫时,需同时给小鼠注射氯喹或伯氨喹,以防止免疫期间发病。
The sporozoites were extracted from salivary glands of Anopheles stephensi infected with NK65 strain of Plasmodium berghei and compared with the immunogenicity of infectious sporozoites after inoculation with high concentration of chloroquine (0.8 mg / ml) or attenuated by γ-ray irradiation. Infectious sporozoites are immunized with mice given either chloroquine or primaquine at the same time to prevent the onset of disease during immunization.