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目的探讨肝炎肝硬化骨髓超微结构改变对血清乳酸脱氢酶(LDH)的影响及其临床意义。方法对代偿期(代偿期组)及失代偿期(失代偿期组)肝炎肝硬化各13例共26例患者骨髓造血微环境及三系血细胞超微结构进行观察。结果骨髓造血微环境损害,三系血细胞出现不同程度病态造血,血清LDH活性升高。结论血清LDH活性升高与骨髓超微环境损害呈相关关系,对预测全面生存具有独立的预后价值。
Objective To investigate the effect of changes in ultrastructure of liver cirrhosis on serum lactate dehydrogenase (LDH) and its clinical significance. Methods The hematopoietic microenvironment and the three-line blood cell ultrastructure of 13 patients with cirrhosis and 13 patients with decompensated (decompensated) and decompensated (decompensated) patients were observed. Results Bone marrow hematopoietic microenvironment damage, three lines of blood cells appeared varying degrees of hematopoietic, serum LDH activity increased. Conclusions The elevated serum LDH activity is correlated with the damage of bone marrow ultramicroenvironment, and has an independent prognostic value in predicting overall survival.