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目的观察布地奈德福莫特罗粉吸入剂治疗儿童中度支气管哮喘的疗效和不良反应及对小呼吸道功能的影响。方法选取青岛大学医学院附属医院哮喘专家门诊初诊的中度支气管哮喘患儿40例,病例均未接受过正规吸入激素治疗。入院后给予布地奈德福莫特罗粉吸入剂,每次1吸,每天2次,治疗12周。分别在治疗4周、8周、12周进行哮喘控制水平(控制、部分控制、未控制)评估,同时测定其肺功能,包括一秒钟用力呼气量(FEV1)占预计值百分比、最大呼气流量(PEF)占预计值百分比、25%用力呼气肺活量(FEF25)、50%用力呼气肺活量(FEF50)、75%用力呼气肺活量(FEF75),并观察不良反应发生情况。对治疗前后肺功能结果进行比较,同时进行病情评估。结果 1.临床控制率:治疗12周,临床控制36例(90%),部分控制4例(10%),总有效率为100%。2.肺功能改善情况:在治疗4周,FEV1、PEF、FEF25、FEF50、FEF75均有显著改善,且在12周的随访过程中,上述指标得到持续改善。治疗12周FEF75、FEF50、FEF25均恢复到正常水平。结论布地奈德福莫特罗粉吸入剂治疗儿童中度支气管哮喘,对缓解症状和改善肺功能均有良好效果,尤其可有效改善哮喘患儿小呼吸道功能,从而达到哮喘临床控制或部分控制,且不良反应发生率低。
Objective To observe the curative effect and side effects of budesonide formoterol powder inhaler on children with moderate bronchial asthma and its effect on the function of small respiratory tract. Methods Forty patients with moderate bronchial asthma newly diagnosed asthma specialist outpatient at Qingdao University Medical College Affiliated Hospital were enrolled. None of the patients received formal inhaled hormone therapy. Admitted to the budesonide formoterol powder inhalation, each suction 1, 2 times a day for 12 weeks. The levels of asthma control (controlled, partially controlled, uncontrolled) were assessed at 4, 8, and 12 weeks of treatment, respectively, and their lung function was measured simultaneously, including forced expiratory volume in one second (FEV1) (PEF), FEF25, FEF50, FEF75, 25%, and adverse reactions were observed. Before and after treatment of lung function results were compared at the same time the condition was assessed. Clinical control rate: 12 weeks of treatment, clinical control in 36 cases (90%), partial control in 4 cases (10%), the total effective rate was 100%. 2. Improvement of pulmonary function: FEV1, PEF, FEF25, FEF50 and FEF75 all improved significantly after 4 weeks of treatment, and the above indexes were continuously improved during the 12-week follow-up. After 12 weeks of treatment, FEF75, FEF50 and FEF25 returned to normal levels. Conclusions Budesonide formoterol powder inhalation for children with moderate bronchial asthma, to relieve symptoms and improve lung function have good effect, especially in children with asthma can effectively improve the small airway function, so as to achieve clinical control or partial control of asthma, And the incidence of adverse reactions is low.