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迄今为止,对弹力蛋白酶是否参与肝纤维化的形成与降解过程知之甚少。细胞外基质(ECM)的弹力纤维随着肝纤维化的进展逐渐增加。我们曾报道正常大鼠肝细胞、肝窦壁内皮细胞等均有弹力蛋白酶mRNA表达。本研究进一步观察了弹力蛋白酶在肝纤维化组织中的表达以及抗肝纤维化药扶正化瘀方对弹力蛋白酶表达的影响。
So far, little is known about whether elastase is involved in the formation and degradation of liver fibrosis. The extracellular matrix (ECM) elastic fibers gradually increase with the progression of hepatic fibrosis. We have reported that normal rat hepatocytes, hepatic sinusoidal endothelial cells, etc. all have elastase mRNA expression. This study further observed the expression of elastase in liver fibrosis and the effect of anti-hepatic fibrosis drug Fuzheng Huayu Recipe on the expression of elastase.