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为测定缩宫素在血浆及组织提取液中的浓度,免疫测定法在很大程度上取代了生物检定法。但是生物检定法仍作为合成缩宫素定量测定的常规方法。虽然英国药典(1980版)列出了缩宫素生物检定的三种标本:鸡血压、大鼠子宫、泌乳大鼠射乳。但是每种标本都存在一定问题。作者报道另一种实用而价廉的可用于合成缩宫素生物检定的标本——雄性小鼠的肛尾肌。业已表明,低浓度的缩
To determine the concentration of oxytocin in plasma and tissue extracts, immunoassays have largely replaced bioassays. However, bioassays are still routinely used for the quantitative determination of oxytocin. Although the British Pharmacopoeia (1980 edition) lists three specimens of the oxytocin bioassay: chicken blood pressure, rat uterus, and lactation in rats. However, there is some problem with each specimen. The authors report another practical and inexpensive specimen that can be used for the bioassay of synthetic oxytocin - the anal tail muscle of male mice. It has been shown that low concentrations of shrinkage