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文章旨在研究冰岛刺参多肽对小鼠免疫调节作用的影响。将小鼠分成7组,每组40只。经口灌胃给予小鼠0、10、30、60、85、170、500 mg/kg冰岛刺参多肽连续15 d。对小鼠免疫器官指数、迟发型变态反应(DTH)、腹腔巨噬细胞吞噬作用、免疫球蛋白含量进行探讨。与对照组相比,冰岛刺参多肽对小鼠DTH有极显著影响(P<0.01),对腹腔巨噬细胞吞噬作用有极显著影响(P<0.01),对免疫球蛋白含量有显著影响(P<0.05)或极显著影响(P<0.01),对小鼠免疫器官指数无明显影响;小鼠免疫功能与冰岛刺参多肽灌胃剂量存在一定剂量效应关系。
The aim of this study was to investigate the effects of the Icelandic sea cucumber polypeptide on immune regulation in mice. The mice were divided into 7 groups of 40. Mice were orally administered 0, 10, 30, 60, 85, 170, 500 mg / kg of Iceland stichopus japonicus polypeptide for 15 consecutive days. Mice immune organ index, delayed-type allergic reaction (DTH), peritoneal macrophage phagocytosis, immunoglobulin content were discussed. Compared with the control group, the Icelandic sea cucumber polypeptide had a very significant effect on DTH (P <0.01), had a very significant effect on phagocytosis of peritoneal macrophages (P <0.01), and had a significant effect on the immunoglobulin content P <0.05), or had a significant effect (P <0.01). There was no significant effect on immune organ index in mice. There was dose-effect relationship between immune function and the intragastric dose of Icelandic sea cucumber polypeptide.