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酮洛芬是一种a-芳基丙酸非甾体抗体炎药物。右酮洛芬(dexketoprofen)多用拆分法得到的酮洛芬的光学异构体[1],其作用几乎为同剂量酮洛芬的2倍,镇痛作用强,起效迅速,不良反应少[2]。目前我国处于新药研制阶段。本实验采用反相HPLC法测定右酮洛芬含量,方法简便,结果准确。
Ketoprofen is a non-steroidal a-aryl propionate antibody drug. The optical isomer of ketoprofen obtained by dexketoprofen multi-resolution method [1] is almost twice as effective as ketoprofen with the strong analgesic effect, rapid onset of action and few adverse reactions [2]. At present, China is in the stage of developing new drugs. In this experiment, reverse-phase HPLC determination of dexketoprofen content, the method is simple and accurate.