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目的探讨复方谷氨酰胺胶囊对妇科恶性肿瘤放疗后肠道反应的保护作用。方法回顾性分析145例接受放射治疗的妇科恶性肿瘤患者,102例在接受放射治疗的同时口服复方谷氨酰胺胶囊(即治疗组),43例在放疗时不使用复方谷氨酰胺胶囊(即对照组)。评价两组患者发生放射性肠炎的情况。结果所有患者均完成了治疗计划,当放疗总剂量达20Gy时,治疗组发生放射性肠炎的比例为30.4%,对照组发生放射性肠炎的比例为48.8%,两组差异具有统计学意义(P<0.05)。放疗计划全部完成后,治疗组发生Ⅲ、Ⅳ级放射性肠炎的比例23.5%,对照组发生Ⅲ、Ⅳ级放射性肠炎的比例41.9%,两组差异具有统计学意义(P<0.05)。然而,放射性肠炎的发生程度在不同的年龄段和不同分期之间差异均无统计学意义(P>0.05)。结论复方谷氨酰胺能降低妇科恶性肿瘤患者放疗后急性肠道反应的程度,也能延缓急性放射性肠道反应的发生时间。
Objective To investigate the protective effect of compound glutamine capsule on the gut reaction of gynecologic malignant tumor after radiotherapy. Methods A retrospective analysis of 145 cases of gynecologic malignancies undergoing radiotherapy was performed. 102 cases received oral compound glutamine capsules (ie, treatment group) while receiving radiotherapy and 43 cases did not use compound glutamine capsules during radiotherapy group). Evaluate the occurrence of radiation enteritis in both groups. Results All the patients completed the treatment plan. When the total dose of radiotherapy was 20 Gy, the incidence of radiation enteritis was 30.4% in the treatment group and 48.8% in the control group, the difference was statistically significant (P <0.05 ). After the completion of the radiotherapy program, the proportion of Ⅲ and Ⅳ grade radiation enteritis occurred in the treatment group and that in the control group was 41.9% and 41.9%, respectively. The differences between the two groups were statistically significant (P <0.05). However, the incidence of radiation enteritis was not significantly different between different age groups and different stages (P> 0.05). Conclusions Compound glutamine can reduce the degree of acute gut reaction in patients with gynecologic malignancies after radiotherapy and also delay the onset of acute radiation-induced intestinal reaction.