TNF-α是一种炎症因子,但近年来其抗炎作用越来越受到人们的重视。TNF-α通过与不同的TNF受体(TNF receptor,TNFR)结合,经过相应的信号转导通路,可产生与促进、维持炎症截然相反的抑制炎症的生理效应。而在它的抗炎作用中,TNF-α与Treg细胞的正性互动起到了重要的作用。本文着重从TNF-α与TNFR结合,促进Treg增殖、功能等角度来介绍近年对于TNF-α抗炎作用的研究进展。 TNF-α is an inflammatory factor, but its anti-inflammatory effect in recent years more and more attention. TNF-α binds to different TNF receptors (TNFRs) through the corresponding signal transduction pathways, and can produce the physiological effects of suppressing inflammation as opposed to promoting and maintaining inflammation. In its anti-inflammatory role, TNF-α and Treg cells positive interaction has played an important role. This article focuses on the combination of TNF-α and TNFR, promote Treg proliferation, function and other aspects to introduce the recent research progress on the anti-inflammatory effect of TNF-α.