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目的 :探讨MT1-MMPmRNA和MT5 -MMPmRNA在肾细胞癌组织中的表达情况及其意义。方法 :采用原位杂交方法对 2 6例肾细胞癌 (RCC)组织中两种基因的表达进行检测。结果 :MT1-MMP和MT5 -MMPmRNA在RCC中的表达明显高于正常组织并且同肿瘤的分期密切相关 ,不同病理组织类型之间的表达无显著差异。结论 :MT1-MMP ,MT5 -MMP在RCC的进展中起到了一定的作用 ,不同病理类型肿瘤组织之间两种基因的表达无显著差异。
Objective: To investigate the expression and significance of MT1-MMP mRNA and MT5-MMP in renal cell carcinoma. Methods: In situ hybridization was used to detect the expression of two genes in 26 cases of renal cell carcinoma (RCC). Results: The expressions of MT1-MMP and MT5-MMP in RCC were significantly higher than those in normal tissues and closely related to the tumor stage. There was no significant difference between the different pathological types. CONCLUSION: MT1-MMP and MT5-MMP play a role in the progression of RCC. There is no significant difference in the expression of two genes between tumor tissues of different pathological types.