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目的探讨临床药师干预对胫腓骨骨折患者抗菌药物费用的影响。方法选择2010年我院未实施临床药师干预时期在我院住院治疗的31例胫骨骨折患者为对照组;另选择实施临床药师干预时期(2011~2014年)在我院住院治疗的126例胫腓骨骨折患者为观察组,其中2011年住院患者为观察1组(26例)、2012年为观察2组(42例)、2013年为观察3组(26例)、2014年为观察4组(32例)。利用方差分析法比较各组患者抗菌药物的年平均费用。结果 5组患者抗菌药物的平均费用比较,差异均有统计学意义(F=56.812,P=0.000)。各观察组患者抗菌药物的平均费用均明显降低于对照组(P<0.05);随着临床药师干预经验的增加,抗菌药物平均费用随着年份增加而降低(P<0.05)。结论临床药师干预胫腓骨骨折患者的治疗能降低抗菌药物费用,为临床药师的工作模式和效果提供了参考。
Objective To investigate the effect of clinical pharmacist intervention on the cost of antibiotics in patients with tibiofibular fractures. Methods Totally 31 tibial fractures hospitalized in our hospital were selected as control group in our hospital without the intervention of clinical pharmacists in 2010. Another 126 patients with tibiofibular fibrosis who were hospitalized in our hospital during the period of clinical pharmacist intervention (2011 ~ 2014) The fracture patients were observation group, of which inpatient observation group 1 (26 cases) in 2011, observation group 2 (42 cases) in 2012, observation group 3 (26 cases) in 2013 and observation group 4 example). ANOVAs were used to compare the annual average cost of antibacterials in each group. Results The average cost of antibacterials in 5 groups was statistically significant (F = 56.812, P = 0.000). The average cost of antimicrobial drugs in each observation group was significantly lower than that of the control group (P <0.05). With the increase of clinical pharmacist intervention, the average cost of antimicrobial drugs decreased with the increase of the year (P <0.05). Conclusion The intervention of clinical pharmacists in the treatment of patients with tibia and fibula fractures can reduce the cost of antimicrobial drugs, which provides a reference for clinical pharmacists’ work mode and effect.