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目的:利用超声心动图评价儿童房间隔缺损(ASD)合并肺动脉高压(PAH)患者导管封堵术后左房大小和功能的变化。方法:选择成功施行封堵治疗的儿童继发孔型ASD合并PAH患者112例和于治疗前和治疗后1d、3个月、6个月、1年行经胸超声心动图检查,测量左房前后径及左房相关容积。心导管测肺动脉压及分流量。结果:治疗后1d,左房前后径与治疗前比较差异无统计学意义(P>0.05),治疗后3个月、6个月、1年左房前后径减小,与治疗前比较差异有统计学意义(P<0.05);治疗后1d、3个月、6个月、1年,肺动脉压力、左房最大、最小、收缩前容积较治疗前有明显差异(P<0.05);治疗后1d,左房整体射血分数、左房被动射血分数、左房主动射血分数与治疗前比较差异无统计学意义(P>0.05);治疗后3个月、6个月、1年,与治疗前比较差异均有统计学意义(P<0.05)。结论:儿童继发孔型ASD合并PAH患者封堵治疗后左房形态及功能明显改善。
Objective: To evaluate the change of left atrium size and function after catheterization in children with atrial septal defect (ASD) and pulmonary hypertension (PAH) by echocardiography. Methods: A total of 112 children with ASD complicated with PAH who had been successfully treated by occlusion were selected, and transthoracic echocardiography was performed before treatment, 1 day, 3 months, 6 months and 1 year after treatment. Path and left atrium-related volume. Cardiac catheterization pulmonary artery pressure and sub-flow. Results: There was no significant difference in the anteroposterior diameter of the left atrium between the two groups (P> 0.05) at 1 day after treatment. The anteroposterior diameter of the left atrium at 3 months, 6 months and 1 year after treatment decreased compared with those before treatment (P <0.05). After 1, 3, 6, and 1 year after treatment, pulmonary artery pressure, left atrium maximum, minimum and pre-contraction volume were significantly different from those before treatment (P <0.05) There was no significant difference in the left atrium ejection fraction, the left atrium passive ejection fraction and the left atrium active ejection fraction between the two groups (P> 0.05) Compared with the pre-treatment difference was statistically significant (P <0.05). Conclusion: The morphology and function of left atrium in children with secondary perforation ASD combined with PAH are significantly improved after closure.