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卵巢癌很快播散到腹腔内腹膜表面并发生腹水,虽然手术尽量切除病灶,并静脉输入抗癌药物,但效果仍不满意。1955年Weisberger等曾给6例卵巢癌合并腹水病人腹腔内注入氮芥(nitrogen mustard),3例病人未再发生腹水,2例病人部分缓解。彼等认为药物注入腹腔可以直接杀死肿瘤细胞,减少腹水的发生。但副作用较严重,如腹痛、恶心、呕吐和腹部痉挛等,因此限制了氮芥在腹腔内的应用。1968年Kottmeier试用腹腔内注入噻替派(thio-tepa)治疗卵巢癌,但未发现有任何直接的效果。在这些早期试验中,病人有限,注射药量少,故结果不满意。
Ovarian cancer quickly spread to the peritoneal peritoneal surface and the occurrence of ascites, although surgery to remove the lesion as much as possible, and intravenous input of anti-cancer drugs, but the effect is still not satisfied. In 1955, Weisberger et al. Injected nitrogen mustard into 6 patients with ovarian cancer complicated with ascites intraperitoneally. No ascites was found in 3 patients and 2 patients were partly relieved. They think the injection of drugs into the abdominal cavity can directly kill tumor cells and reduce the incidence of ascites. However, more serious side effects, such as abdominal pain, nausea, vomiting and abdominal cramps, thus limiting the nitrogen mustard intraperitoneally. In 1968 Kottmeier tried intraperitoneal injection of thio-tepa for the treatment of ovarian cancer, but found no immediate effect. In these early trials, the patient was limited and there was little injection and the results were unsatisfactory.