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目的了解山东省寿光市孕产妇传染性病原体感染情况,以采取针对性预防措施。方法 2013—2015年,对在山东省寿光市妇幼保健院就诊的孕产妇用酶联免疫吸附法检测乙型肝炎病毒标志物(HBV-M)、丙型肝炎抗体(抗-HCV)和艾滋病抗体(抗-HIV),用甲苯胺红不加热血清试验法检测梅毒抗体。结果共检测15 056名孕产妇,年龄18~46岁,HBs Ag、抗-HBs、抗-HCV、梅毒抗体和抗-HIV阳性率分别为3.31%、61.71%、0.01%、0.03%和0.00;HBs Ag阳性血清中有479份做进一步检测,HBV-M共有6种组合模式,其中HBs Ag、抗-HBe和抗-HBc阳性(“小三阳”)所占比例最高(49.27%),HBs Ag、HBe Ag和抗-HBc Ag阳性(“大三阳”)次之(35.28%);在全部HBV-M检测结果中,抗-HBc、抗-HBe、HBe Ag阳性率分别为91.65%、49.69%和43.42%,单项HBs Ag阳性率仅占0.63%。结论孕产妇存在一定程度的传染性病原体感染,做好产前检测,对预防和控制母婴传播,防止交叉感染具有重要意义。
Objective To understand the infection status of maternal infectious pathogens in Shouguang City, Shandong Province, so as to take targeted preventive measures. Methods From 2013 to 2015, HBV-M, HCV and anti-HCV were detected by enzyme-linked immunosorbent assay (ELISA) in maternity women at MCH hospital in Shouguang, Shandong Province. (Anti-HIV), with toluidine red unheated serum test syphilis antibody. Results A total of 15 056 pregnant women aged 18-46 years were tested. The positive rates of HBsAg, anti-HBs, anti-HCV, syphilis and anti-HIV were 3.31%, 61.71%, 0.01%, 0.03% Among the 479 HBsAg-positive sera, HBV-M combined with 6 combinations showed the highest proportion of HBs Ag, anti-HBe and anti-HBc (49.27%), The positive rates of HBs Ag, HBe Ag and anti-HBc Ag were the highest (35.28%). The positive rates of anti-HBc, anti-HBe and HBe Ag in all the HBV-M test results were 91.65%, 49.69% and 43.42% respectively. The positive rate of single HBsAg was only 0.63%. Conclusion There is a certain degree of infectious pathogens infection in pregnant women, prenatal testing, prevention and control of mother-to-child transmission, prevention of cross-infection is of great significance.