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目的:系统评价蒙脱石散保留灌肠治疗婴幼儿轮状病毒肠炎的临床疗效和安全性。方法:计算机检索Cochrane Library、Pub Med、中国生物医学数据库、万方数据库、中国学术期刊网络出版总库和维普数据库,收集应用蒙脱石散保留灌肠治疗婴幼儿轮状病毒肠炎的随机对照研究文献,检索年限均截至2014年1月。由2名评价员独立筛选合格文献并提取相关信息,应用Rev Man5.2软件进行统计学分析。结果:纳入随机对照试验研究20项,共2 484例轮状病毒肠炎患儿。对纳入的研究进行Meta分析结果显示,各独立研究间无统计学异质性,合并分析后效应值RR=1.20,95%CI(1.17,1.24),蒙脱石散保留灌肠组的临床疗效优于对照组,差异有统计学意义(P<0.05)。发表偏倚分析提示纳入研究的文献存在发表偏倚可能。结论:蒙脱石散保留灌肠在治疗轮状病毒肠炎上具有提高临床愈显率的优势。
OBJECTIVE: To systematically evaluate the clinical efficacy and safety of montmorillonite powder retention enema in the treatment of infantile rotavirus enteritis. Methods: A randomized controlled clinical trial was conducted to collect the Cochrane Library, Pub Med, China Biomedical Database, Wanfang Database, China Academic Journals Online Database and VIP Database. , The search period is as of January 2014. Two reviewers independently screened qualified documents and extracted relevant information, using Rev Man5.2 software for statistical analysis. Results: Twenty randomized controlled trials were enrolled, with a total of 2 484 children with rotavirus enteritis. Meta-analysis of the included studies showed that there was no statistical heterogeneity among the independent studies. The combined effect after the analysis was RR = 1.20, 95% CI (1.17, 1.24). The clinical efficacy of the montmorillonite saponinate retention enema group In the control group, the difference was statistically significant (P <0.05). Post-publication bias analysis suggests publication bias may exist in the literature included. Conclusion: The montmorillonite powder retention enema has the advantage of improving the clinical cure rate in the treatment of rotavirus enteritis.