东莨菪碱对猕猴吗啡静脉自身给药及反应恢复的影响

来源 :中国临床药理学与治疗学杂志 | 被引量 : 0次 | 上传用户:yc668
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目的研究M胆碱能受体阻滞剂东莨菪碱对猕猴吗啡静脉自身给药及反应恢复行为的影响。方法建立猕猴吗啡静脉自身给药模型(固定比率1 ,给药期4h)以及反应恢复模型。观察不同浓度东莨菪碱急性处理对吗啡静脉自身给药模式、踏板反应率、吗啡用药量以及自由活动度的影响。同时观察慢性和急性东莨菪碱处理对静脉自身给药行为淬灭后反应恢复行为的影响。结果东莨菪碱急性处理(0.025,0.075,0.25,0.75mg/kg)可以减弱FR1程序控制下吗啡静脉自身给药行为 ,不仅表现为总用药量和反应速率的降低 ,而且还可延迟自身给药行为的起动 ,同时对自身给药行为模式有较大的影响 ,小剂量东莨菪碱可使急促的用药行为变为缓慢 ,大剂量时几乎可完全阻断动物的踏板反应。反应恢复实验结果显示 ,东莨菪碱急性处理可延迟淬灭后踏板反应的恢复 ,而慢性处理可降低动物的踏板反应率及总的强化次数。结论提示东莨菪碱对复吸行为可能有一定的治疗作用 Objective To investigate the effect of scopolamine, a cholinergic receptor antagonist, on the self-administration of morphine in rhesus monkeys and the recovery of response. Methods The self-administration model of morphine in rhesus monkeys (fixed ratio of 1, dosing period of 4 h) and the model of reaction recovery were established. The effects of different concentrations of scopolamine on morphine self-administration mode, pedal reaction rate, morphine dosage and free activity were observed. At the same time, the effects of chronic and acute scopolamine treatment on the recovery behavior after intravenous self-administration were quenched. Results The acute administration of scopolamine (0.025,0.075,0.25,0.75mg / kg) attenuated the self-administration of morphine vein under the control of the FR1 program, not only showing a decrease in the total dose and reaction rate but also delayed self-administration Start-up, at the same time on their own mode of administration has a greater impact on the drug, low-dose scopolamine can make rapid drug behavior becomes slow, high doses can almost completely block the animal pedal reaction. The experimental results of response recovery showed that the acute treatment of scopolamine delayed the recovery of the pedal reaction after quenching, while the chronic treatment reduced the pedal reaction rate and the total enhancement times of the animals. Conclusions suggest that scopolamine may have a therapeutic effect on relapse
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