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目的:观察健脾益气汤联合恩丹西酮对大肠癌化疗后消化功能的疗效。方法:将60例大肠癌拟行FOL-FOX4方案化疗患者随机分为对照组、联合组各30例,联合组化疗前予恩丹西酮静脉推注,联合组在对照组基础上加服健脾益气汤;观察两组疗效。结果:联合组消化道反应明显低于对照组(P<0.05),且生存质量高于对照组(P<0.05);联合组腹胀、便秘明显少于对照组。结论:健脾益气汤联合恩丹西酮能明显减轻大肠癌化疗后消化道反应,提高患者生存质量,且能防治恩丹西酮的不良反应,适合临床推广。
Objective: To observe the effect of Jianpi Yiqi decoction combined with ondansetron on digestive function of patients with colorectal cancer after chemotherapy. Methods: Sixty patients with colorectal cancer who underwent FOL-FOX4 regimen were randomly divided into control group (n = 30) and combination group (n = 30). Patients in combination group received ondansetron intravenous injection before chemotherapy. Spleen Yiqi Tang; observed two groups curative effect. Results: The gastrointestinal reaction in the combination group was significantly lower than that in the control group (P <0.05), and the quality of life was higher than that in the control group (P <0.05). The bloating and constipation in the combination group were significantly less than those in the control group. Conclusion: Jianpi Yiqi Decoction combined with ondansetron can obviously relieve the gastrointestinal reaction after chemotherapy and improve the quality of life of patients with colorectal cancer, and can prevent side effects of ondansetron, which is suitable for clinical promotion.