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采用氢气清除法测定胃粘膜血流量(gastric mucosal blood flow,GMBF),以及用利多卡因消除十二指肠传入信息的技术,观察传入信息在十二指肠灌注高渗盐溶液对外源性五肽胃泌素(pentagastrin,G_5)引起的胃酸分泌和 GMBF 抑制效应中的作用。结果表明:(1)静脉灌注 G_5引起胃酸分泌和 GMBF 增加;(2)十二指肠灌注高渗盐溶液可使 G_5激发的胃酸分泌明显减少,而 GMBF 不再增高;(3)使用利多卡因后,在十二指肠灌注高渗盐溶液对胃酸分泌和 GMBF 的抑制性影响消除。这提示十二指肠传入信息不仅可调节生理性胃酸分泌,而且在十二指肠内灌注高渗盐溶液对 G_5刺激胃酸分泌和 GMBF 的抑制性效应中亦有作用。
Gastric mucosal blood flow (GMBF) was measured by hydrogen scavenging method and the technique of eliminating the afferent information of duodenum with lidocaine was used to observe the effect of the influx of duodenal perfused hypertonic saline solution on the exogenous Role of pentagastrin (G_5) in gastric acid secretion and GMBF inhibitory effect. The results showed that: (1) gastric acid secretion and GMBF increased after intravenous infusion of G_5; (2) gastric juice secretion induced by G_5 significantly decreased after perfusion of hypertonic saline solution into duodenum, while GMBF no longer increased; (3) After the duodenal infusion of hypertonic saline solution to eliminate gastric acid secretion and GMBF inhibitory effect. This suggests that duodenal afferent information not only regulates physiological gastric acid secretion, but also plays a role in the duodenal infusion of hypertonic saline solution on G_5-stimulated gastric acid secretion and inhibitory effects of GMBF.