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目的探讨子宫内膜癌中雌激素受体(ER)、孕激素受体(PR)和p53的表达及其临床意义。方法 1994年1月2009年11月,应用免疫组织化学Envision法检测52例子宫内膜癌中ER、PR和p53的表达情况并进行统计学分析。结果 ER、PR和p53阳性表达率分别为51.9%、50.0%和46.2%。ER、PR的阳性表达率与癌组织的细胞分化程度有关(P<0.05)。随着组织学分级的增高,ER、PR阳性表达率逐渐降低(在Ⅰ、Ⅱ和Ⅲ级子宫内膜癌中,ER阳性表达率分别为64.0%、56.3%和18.2%,PR阳性表达率分别为72.0%、37.5%和18.2%)。随着组织学分级的增高及淋巴结转移,p53的阳性表达率逐渐增高(P<0.05),p53表达与ER、PR表达有关(P<0.05)。结论 ER、PR和p53的表达与子宫内膜癌组织学分级和生物学行为密切相关,其测定对评估子宫内膜癌预后,指导临床治疗具有重要意义。
Objective To investigate the expression of estrogen receptor (ER), progesterone receptor (PR) and p53 in endometrial carcinoma and its clinical significance. Methods January 1994, November 2009, immunohistochemical Envision method was used to detect the expression of ER, PR and p53 in 52 cases of endometrial carcinoma and statistical analysis. Results The positive rates of ER, PR and p53 were 51.9%, 50.0% and 46.2% respectively. The positive rates of ER and PR were related to the degree of cell differentiation (P <0.05). With the increase of histological grade, the positive rates of ER and PR decreased gradually (the positive rates of ER were 64.0%, 56.3% and 18.2% respectively in grade Ⅰ, Ⅱ and Ⅲ endometrial carcinoma, the positive rate of PR were respectively 72.0%, 37.5% and 18.2%). With the increase of histological grade and lymph node metastasis, the positive rate of p53 was increased (P <0.05), and the expression of p53 was correlated with the expression of ER and PR (P <0.05). Conclusion The expressions of ER, PR and p53 are closely related to the histological grade and biological behavior of endometrial carcinoma. The determination of ER, PR and p53 is of great significance in evaluating the prognosis of endometrial carcinoma and guiding the clinical treatment.