日本研究开发公司用小鼠作实验,发现结核菌素抗原与免疫激活剂OK-432合用,可使鼠体内肿瘤坏死因子(TNF)的产生增加10～100倍.若用于治疗癌症小鼠,则可使肿瘤停止生长.在人体研究中,对用化学疗法治疗无效的肺癌复发病人,在用结核菌素抗原治疗后再给予OK-432,结果病人血清TNF水平激增,癌症损害缩小. The Japanese research and development company used mice for experiments and found that the combination of tuberculin antigen and the immune activator OK-432 can increase the production of tumor necrosis factor (TNF) by 10 to 100 times in mice. If it is used to treat cancer mice, The tumor can be stopped growing. In human studies, patients with relapsed lung cancer who have failed chemotherapy treatment are given OK-432 after treatment with tuberculin antigen. As a result, the patient’s serum TNF level increases sharply, and cancer damage is reduced.