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目的:分析多模态影像定量参数对肝硬化结节性质的鉴别诊断价值。方法:抽取2018年1月至2020年12月南阳市中心医院收治的肝硬化结节患者80例，按病理诊断结果分为肝癌组(49例)和结节组(31例)。两组均行CT、超声造影(CEUS)、磁共振成像(MRI)检查，比较不同方法的检出率及CT定量参数包括血流量(BF)、血容量(BV)、表面通透性(PS)，CEUS定量参数包括开始增强时间(AT)、达峰时间(TTP)、峰值强度(PI)，不同时期CEUS定量参数包括局部血容量(RBV)、局部血流量(RBF)，并比较动态增强磁共振成像(DCE-MRI)参数包括纯扩散系数(D)、灌注分数(f)、表观扩散系数(ADC)。结果:CT、CEUS、MRI联合诊断的肝癌检出率及增生结节检出率分别为91.84%(45/49)、96.77%(30/31)，均高于三者单独诊断(n P均<0.05)。肝癌组BF、BV、PS参数和AT、TTP参数低于结节组，PI参数高于结节组(n P<0.05)。肝癌组动脉期RBV、RBF参数高于结节组，门脉期和延迟期RBV参数低于结节组(n P<0.05)。肝癌组D值、ADC值低于结节组，f值高于结节组(n P<0.05)。n 结论:在肝硬化结节患者中，肝癌和增生结节多模态影像定量参数存在较大差异，多检查方法联合检测能全面反映机体病理生理变化，利于提高检出率。“,”Objective:To analyze the application value of multimodal imaging quantitative parameters in the differential diagnosis of liver cirrhosis nodules.Methods:Eighty patients with liver cirrhosis complicated with occupied diseases in Nanyang Central Hospital from January 2018 to December 2020 were selected and divided into liver cancer group (49 cases) and nodular group (31 cases) according to pathological diagnosis results. All patients were diagnosed by CT, contrast-enhanced ultrasound (CEUS) and magnetic resonance imaging (MRI). The detection rate, CT quantitative parameters, including blood flow (BF), blood volume (BV), permeability surface (PS), CEUS quantitative parameters, including arrival time (AT), time to peak (TTP), peak intensity (PI), and CEUS quantitative parameters in different periods, including regional blood volume (RBV) and regional blood flow (RBF) were compared, and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters, including pure diffusion coefficient (D), perfusion fraction (f), apparent diffusion coefficient (ADC) were compared.Results:The detection rates of liver cancer and hyperplasia nodules in CT, CEUS and MRI combined diagnosis were 91.84% (45/49) and 96.77% (30/31), respectively, which were higher than those of the CT, CEUS and MRI alone (all n P<0.05). The parameters of BF, BV, PS, AT and TTP in liver cancer group were lower than those in nodule group, while PI was higher than that in nodule group (n P<0.05). The RBV and RBF parameters in the arterial phase of liver cancer group were higher than those in nodule group, and the RBV parameters in the portal and delayed phases were lower than those in nodule group (n P<0.05). The D value and ADC value of liver cancer group were lower than those of nodule group, while the f value was higher than that of nodule group (n P<0.05).n Conclusions:In patients with liver cirrhosis nodules, there are great differences in the quantitative parameters of multimodal images between liver cancer and proliferative nodules. The combined detection of multiple examination methods can reflect the pathophysiological changes of the body comprehensively, which is beneficial to improve the detection rate.