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目的研究利多卡因及其代谢产物单乙基甘氨酰二甲苯胺(MEGX)在蛛网膜下腔麻醉致死犬体内的死后再分布规律。方法犬6只随机分为A、B两组,分别经蛛网膜下腔注射0.5倍(6.34mg/kg)和5倍(63.35mg/kg)硬膜外麻醉极量的盐酸利多卡因,于死后0h、12h、24h、36h、72h取心血、外周血、肝、脑等,采用高效液相色谱法(HPLC)检测其中利多卡因及MEGX的含量。结果 A组犬死后72h,心血、外周血和脑中利多卡因含量与死亡当时的比值(Ct/C0)分别为4.74,14.87,7.67,均呈上升趋势(P<0.05),MEGX含量与死亡当时含量差异无统计学意义(P>0.05);B组犬死后72h,心血中利多卡因含量Ct/C0值为0.36,呈下降趋势(P<0.05),脑中为3.48(P<0.05)呈升高的趋势,肝中MEGX含量与死亡当时相比差异无统计学意义(P>0.05)。结论蛛网膜下腔不同剂量麻醉致死犬体内利多卡因均会发生死后再分布,MEGX未发生死后再分布。
Objective To study the post-mortem redistribution of lidocaine and its metabolite monoethylglycyldiamine (MEGX) in dogs after subarachnoid anesthesia. Methods Six dogs were randomly divided into A and B groups. Epidural lidocaine hydrochloride (0.54-fold, 6.35 mg / kg) and epidural lidocaine (5-fold, 63.35 mg / Cardiac blood, peripheral blood, liver and brain were taken at 0h, 12h, 24h, 36h and 72h after death, and the contents of lidocaine and MEGX were detected by high performance liquid chromatography (HPLC). Results The ratio of Ct / C0 to the prevalence of death at 72h after treatment in group A was 4.74, 14.87 and 7.67, respectively, showing an upward trend (P <0.05). The ratio of MEGX to death There was no significant difference between the two groups (P> 0.05). At 72h after death, the Ct / C0 value of lidocaine in group B was 0.36 (P <0.05) (P> 0.05). There was no significant difference in the content of MEGX in liver compared with the time of death (P> 0.05). Conclusion All doses of lidocaine in dogs after subarachnoid anesthesia caused by lidocaine died after reperfusion. MEGX did not appear to be redistributed after the death.