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目的调查体检女性血糖血脂水平的动态变化,探讨年龄和雌二醇与血糖血脂的相关性及意义。方法收集近5年来体检女性标本1 783例,其中绝经女性532例,人群按10年为间隔分为5组。测定血清E2、血糖和血脂,计算非高密度脂蛋白胆固醇(non-HDL-C)和血浆致动脉硬化指数(AIP)。结果 5个年龄组GLU、TG、TC、LDL-C、nonHDL-C和AIP浓度的差异均有统计学意义(P<0.05),各年龄组的上述参数水平随年龄增长逐渐升高。绝经组的上述参数水平显著高于未绝经组,高胆固醇血症和高甘油三酯血症患病率显著高于未绝经组,差异均有统计学意义(P<0.05)。年龄与上述参数呈正相关,控制年龄后偏相关显示E2与上述参数呈负相关,与HDL-C呈正相关。多元线性回归进一步提示E2水平与AIP、non-HDL-C和GLU呈负相关。结论女性随年龄增长血糖血脂逐渐升高,绝经后雌激素缺乏加重血糖血脂异常,补充外源性雌激素可有效降低血糖血脂水平。
Objective To investigate the dynamic changes of blood glucose and blood lipids in women with physical examination, and to explore the correlation between age, estradiol and blood glucose and blood lipid. Methods A total of 1 783 female specimens were collected during the past 5 years, of whom 532 were postmenopausal women. The population was divided into 5 groups at intervals of 10 years. Serum E2, blood glucose and blood lipids were measured to calculate non-HDL-C and AIP. Results There were significant differences in the concentrations of GLU, TG, TC, LDL-C, non-HDL-C and AIP between the 5 age groups (P <0.05). The above parameters of all age groups increased gradually with age. The above parameters in menopause group were significantly higher than those in non-menopause group. The prevalence of hypercholesterolemia and hypertriglyceridemia were significantly higher than those in non-menopause group (P <0.05). There was a positive correlation between age and the above parameters. The age-related partial correlation showed that E2 was negatively correlated with the above parameters and positively correlated with HDL-C. Multiple linear regression further suggested that E2 levels were negatively correlated with AIP, non-HDL-C and GLU. Conclusion Female with age increased blood glucose and blood lipids gradually increased postmenopausal estrogen deficiency aggravate dyslipidemia, supplemented with exogenous estrogen can effectively reduce blood glucose and blood lipid levels.