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目的 对止血敏磁控缓释微球 (止血敏微球 )进行兔胃靶向试验 ,观察其靶向和止血效力。方法 用X线摄影观察止血敏微球在兔胃的分布情况 ,用分光光度测量法检测靶区的止血敏含量 ,观察其在兔胃的止血功效。结果 止血敏微球能有效地准确定位于胃靶区 ,微球在磁场强度 0 .49T ,梯度 0 .2 3T/cm状态下可产生 2 8cm水柱的压力 ;胃靶区粘摸层止血敏含量检测结果 :磁控组、非磁控组和静脉组的平均含量分别为 (1869± 15 0 ) μg/ g ,(10 8±2 2 ) μg/ g ,(3 0±5 ) μg/ g ;磁控组是非磁控组的 17倍 ,是静脉组的62倍。经统计学分析 ,P <0 .0 1。可在 10min内明显控制兔胃小动脉活动性出血 ,对照组则需 3 0min以上。结论 止血敏磁控缓释微球有可能成为治疗上消化道大出血的理想药物和一种新的简便而有效的非手术疗法
Objective To observe the targeting and hemostatic effect of a gastrin-releasing microspheres (hemostatic microspheres) for the purpose of the rabbit stomach targeting test. Methods X-ray photography was used to observe the distribution of antisera microspheres in the stomach of rabbits. The content of antisera in the target area was detected by spectrophotometry and the hemostatic effect in the stomach of rabbits was observed. Results The hemostatic microspheres could be accurately localized in the stomach target area. The microspheres could produce a pressure of 28 cm water column at a magnetic field strength of 0.49 T and a gradient of 0.23 T / cm. The results showed that the average contents of magnetron group, non-magnetron group and vein group were (1869 ± 15 0) μg / g, (10 8 ± 2 2) μg / g, (3 0 ± 5) μg / g, Magnetic control group is non-magnetic control group 17 times, 62 times that of the vein group. After statistical analysis, P <0. Can be significantly controlled within 10min rabbit arteriolar bleeding, the control group need more than 30min. CONCLUSIONS: The dexamethasone-releasing microspheres may become the ideal drug for the treatment of upper gastrointestinal bleeding and a new simple and effective non-surgical treatment