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目的分析联合应用hs-CRP与外周血淋巴细胞计数两个指标在急性心肌梗死(AMI)发作期间改变与心功能的相互关系,以探讨与AMI预后的相关性。方法测定健康志愿者81例(对照组)和急性心肌梗死患者86例的血清hs-CRP浓度及外周血淋巴细胞计数,同时以彩色多普勒超声检测并计算左室射血分数(LVEF)及左室后壁收缩期增厚率(△T%)。结果AMI Ⅰ组、Ⅱ组、Ⅲ组和Ⅳ组中血清hs-CRP水平明显高于对照组,并随心功能Killip分级的严重程度增加而升高,而外周血淋巴细胞计数则相反,两组比较差异有统计学意义(P<0.001);血清hs-CRP水平与心功能Killip分级呈负相关(r=-0.38,P<0.01),外周血淋巴细胞计数水平与心功能Killip分级呈正相关(r=0.97,P<0.01)。结论急性心肌梗死患者血清hs-CRP水平明显升高,与心功能Killip分级呈负相关,而外周血淋巴细胞计数水平明显降低,与心功能Killip分级呈正相关。
Objective To analyze the relationship between cardiac function and the changes of hs-CRP and peripheral blood lymphocyte counts during the onset of acute myocardial infarction (AMI) in order to explore the correlation with the prognosis of AMI. Methods Serum hs-CRP levels and peripheral blood lymphocyte counts were measured in 81 healthy volunteers (control group) and 86 patients with acute myocardial infarction. The left ventricular ejection fraction (LVEF) and the left ventricular ejection fraction (LVEF) were measured by color Doppler sonography. Left ventricular posterior wall systolic thickening rate (△ T%). Results The serum levels of hs-CRP in AMI group Ⅰ, Ⅱ group, Ⅲ group and Ⅳ group were significantly higher than those in control group, and increased with the severity of cardiac function Killip classification, while the peripheral blood lymphocyte count was the opposite. The level of hs-CRP was negatively correlated with Killip grade (r = -0.38, P <0.01). There was a positive correlation between peripheral blood lymphocyte count and cardiac function Killip classification (r = 0.97, P <0.01). Conclusions Serum hs-CRP levels in patients with acute myocardial infarction were significantly higher than those in patients with acute myocardial infarction. The level of serum hs-CRP was negatively correlated with Killip grade, while the level of peripheral blood lymphocyte counts was significantly lower, which was positively correlated with Killip grade.