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观察化学诱变剂甲基硝基亚硝胍（ＭＮＮＧ）引起的非洲绿猴肾ｖｅｒｏ细胞非定标性突变率的时相变化，继而在突变率最高时点分别以ＲＮＡ合成抑制剂和蛋白质合成抑制剂阻断基因转录和翻译。结果发现前者能使ＭＮＮＧ引起的非定标性突变率下降到对照水平，而后者反而使突变率增高。提示非定标性突变形成过程中可能发生基因表达改变，并提出引起这种改变的细胞信号传导通路假设和今后的研究方向。
To observe the time-dependent changes of the non-scale mutation rate of the green monkey kidney vero cells induced by the chemical mutagen methyl-nitrosoguanidine (MNNG), and then to synthesize inhibitors and proteins respectively at the highest mutation rate Inhibitors block gene transcription and translation. The results showed that the former can make MNNG induced non-standard mutation rate dropped to the control level, while the latter increased the mutation rate. It is suggested that the gene expression may change during the process of non-standard mutation formation, and the assumptions and future directions of cell signaling pathways that cause this change are proposed.