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目的:评价甘精胰岛联合瑞格列奈治疗口服降糖药控制血糖不佳的2型糖尿病的有效性和安全性。方法:本组68例口服降糖药物治疗不佳的2型糖尿病患者(空腹血糖>8.5mmol/L,餐后两小时血糖>11mmol/L,HBA1C>8.5%),改用甘精胰岛联合瑞格列奈治疗,进行为期12周的血糖比较。结果:睡前注射一次甘精胰岛,联合三餐前口服瑞格列奈治疗,可使口服降糖药控制不佳的2型糖尿病患者的血糖得到良好控制,且低血糖发生率较应用预混胰岛素低。
OBJECTIVE: To evaluate the efficacy and safety of insulin glargine combined with repaglinide in the treatment of type 2 diabetes with poor blood glucose by oral hypoglycemic agents. Methods: A total of 68 patients with type 2 diabetes (fasting blood glucose> 8.5mmol / L, postprandial blood glucose> 11mmol / L, HBA1C> 8.5%) were enrolled in this study. Gliclazide treatment, for a period of 12 weeks of blood glucose comparison. Results: A glimpse of pancreatic islets at bedtime was injected, and oral administration of repaglinide before three meals a day provided good control of blood glucose in type 2 diabetic patients with poorly controlled oral hypoglycemic agents. The incidence of hypoglycemia was higher Insulin is low.