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目的 :探讨一氧化氮 (NO)对大鼠实验性蛛网膜下腔出血 (SAH)后脑血管痉挛 (CVS)时脑血流 (CBF)的作用。方法 :将 2 4只大鼠随机分成 4组 (n =6 ) :A组假手术 +盐水 ;B组假手术 + NOC12 ;C组 SAH+盐水 ;D组SAH+ NOC12。模型制成 48h后 ,通过 L aser- Doppler血流仪观察 NOC12 (NO供体 )持续静脉注射 1h内 CBF的变化。结果 :A、C组 CBF无变化 ,B、D组 CBF明显增加 ,且 B组增加幅度高于 D组。结论 :NO能有效增加正常对照及 CVS时的 CBF,但 CVS时脑动脉对 NO的反应性下降。
Objective: To investigate the effect of nitric oxide (NO) on cerebral blood flow (CBF) in cerebral vasospasm (CVS) after experimental subarachnoid hemorrhage (SAH) in rats. Methods: 24 rats were randomly divided into 4 groups (n = 6): sham group A + saline; group B sham + NOC12; group C SAH + saline; group D SAH + NOC12. After the model was made for 48h, the changes of CBF within 1h after continuous intravenous injection of NOC12 (NO donor) were observed by L aser-Doppler flowmeter. Results: There was no change in CBF in group A and group C, and CBF in group B and group D were significantly increased, and the increase in group B was higher than that in group D. CONCLUSION: NO can effectively increase the CBF of normal control and CVS, but decrease the reactivity of cerebral artery to NO in CVS.