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中耳免疫在中耳疾病中占有重要地位。现就近年国外有关文献综述于后。一、中耳粘膜免疫概况中耳粘膜具有免疫功能。这种免疫反应不依赖血清免疫球蛋白,而主要表现在粘膜局部,因此,亦有称之为粘膜免疫(mucosal immune)或分泌性免疫(secretory immune)的。中耳粘膜层、粘膜下层和固有层均有丰富的淋巴细胞和浆细胞。固有层内的淋巴细胞、巨噬细胞和浆细胞可摄取抗原物质,携带抗原信息转运入中耳上皮细胞层。浆细胞可局部生成免疫球蛋白,发挥体液免疫作用。在上皮细胞间的淋巴细胞均带有T细胞的标记。这些淋巴细胞具有抗体依赖性细胞介导细胞毒作用(ADCC),能够特异性地杀伤细胞膜。此外,中耳粘膜内的杯状细胞分泌的粘液和浆液与纤毛细胞共同构成粘液纤
Middle ear immunity plays an important role in middle ear disease. Now in recent years, foreign literature review later. First, the middle ear mucosal immunity Middle ear mucosa with immune function. This immune response does not depend on serum immunoglobulin, but mainly in the local mucosal, therefore, also known as mucosal immune (mucosal immune) or secretory immune (secretory immune). Middle ear mucosa, submucosa and lamina propria are rich in lymphocytes and plasma cells. The lamina propria of lymphocytes, macrophages and plasma cells can ingest antigenic material, carry antigen information into the middle ear epithelial cell layer. Plasma cells can generate immunoglobulin local, play a role in humoral immunity. Lymphocytes between epithelial cells carry T-cell markers. These lymphocytes have antibody-dependent cell-mediated cytotoxicity (ADCC) and are able to specifically kill the cell membrane. In addition, the goblet cells in the middle ear mucus secreted mucus and serous fluid together with the ciliated cells to form mucus fibers