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目的 :探讨垂体腺瘤中细胞增殖核抗原 (PCNA)表达与肿瘤发生及生物学行为的关系。方法 :对 6 0例垂体腺瘤患者应用免疫组化SP法检测细胞增殖核抗原在侵袭性垂体腺瘤与非侵袭性垂体腺瘤中的表达。结果 :PCNA的表达在侵袭性腺瘤组明显高于非侵袭性腺瘤组 ,复发组明显高于非复发组。临床方面 ,侵袭性腺瘤组和非侵袭性腺瘤组在肿瘤大小、瘤内出血坏死、囊变发生率方面有显著差异。结论 :PCNA的高表达与垂体腺瘤的发生及生物学行为改变密切相关 ,可做为反映瘤侵袭性的参考指标。侵袭性垂体腺瘤多为大腺瘤 ,肿瘤出血、坏死、囊变发生率高 ,肿瘤增殖能力强。
Objective: To investigate the relationship between the expression of proliferating cell nuclear antigen (PCNA) and tumorigenesis and biological behavior in pituitary adenomas. Methods: Immunohistochemical SP method was used to detect the expression of proliferating cell nuclear antigen (PCNA) in invasive pituitary adenomas and non-invasive pituitary adenomas in 60 patients with pituitary adenoma. Results: The expression of PCNA was significantly higher in invasive adenoma group than in non-invasive adenoma group, and the recurrence group was significantly higher than that in non-recurrence group. Clinically, invasive adenoma group and non-invasive adenoma group in tumor size, tumor hemorrhagic necrosis, the incidence of cystic degeneration have significant differences. Conclusion: The high expression of PCNA is closely related to the occurrence and biological behavior changes of pituitary adenomas, which can be used as a reference index to reflect the invasiveness of tumors. Invasive pituitary adenomas mostly adenoma, tumor hemorrhage, necrosis, high incidence of cystic fibrosis, tumor proliferation ability.