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近年来,血管扩张剂硝普钠治疗心血管疾病日趋普遍。本文就硝普钠的药理、血液动力学作用、临床及毒性反应作一综述。 (一) 药理学及血液动力学作用硝普钠的药理活性成分是亚硝基(NO),在化学上和临床常用的硝酸酯中的硝基(NO_2)相似。硝普钠直接松弛小动脉和小静脉平滑肌,但对胃肠和子宫平滑肌无作用。其对阻力血管和容量血管的
In recent years, vasodilator sodium nitroprusside treatment of cardiovascular disease is becoming more common. This article reviews the pharmacological, hemodynamic effects, clinical and toxic reactions of sodium nitroprusside. (A) Pharmacological and hemodynamic effects Sodium nitroprusside pharmacologically active ingredient is a nitroso (NO), chemically and nitric oxide (NO 2) commonly used in clinical similar. Sodium nitroprusside directly relaxes the arterioles and venules of the smooth muscle, but has no effect on the gastrointestinal and uterine smooth muscles. Its resistance to blood vessels and volume of blood vessels