论文部分内容阅读
目的探讨性激素在食管、贲门癌发病中的作用及临床意义。方法应用放射免疫法对３０例食管、贲门部良性疾病（对照组），４０例食管癌患者（食管癌组），１０例贲门癌患者（贲门癌组）血清睾酮（Ｔ）及雌二醇（Ｅ２）水平进行测定。结果食管癌组Ｔ水平较对照组高（Ｐ＞０．０５），贲门癌组低于对照组（Ｐ＜０．０５）。食管癌组和贲门癌组Ｅ２水平均低于对照组（Ｐ＜０．０１，Ｐ＜０．０５），而术后Ｅ２水平高于术前（Ｐ＜０．０５）。Ｅ２水平与病理分级及癌肿复发有关，Ｔ水平与分级间无差异（Ｐ＞０．０５）。结论性激素在食管癌与贲门癌的发生、发展中起着一定的作用；Ｅ２水平的变化可作为手术指征及预后的一项参考指标，并为性激素治疗食管癌的可能性提供了一定的理论依据。
Objective To investigate the role and clinical significance of sex hormones in the pathogenesis of esophageal and cardiac cancers. Methods Radioimmunoassay was used to detect serum testosterone (T) and estradiol in 30 patients with esophageal and cardiac benign diseases (control group), 40 patients with esophageal cancer (esophageal cancer group), and 10 patients with cardiac cancer (cardia cancer group). E2) The level is measured. Results The level of T in the esophageal cancer group was higher than that in the control group (P>0.05). The cardiac cancer group was lower than the control group (P<0.05). E2 levels in the esophageal cancer and cardiac cancer groups were lower than those in the control group (P<0.01, P<0.05), and E2 levels after surgery were significantly higher than before surgery (P<0.05). E2 level was associated with pathological grade and recurrence of cancer. There was no difference between T level and grade (P>0.05). Conclusion The sex hormone plays a certain role in the occurrence and development of esophageal and cardiac cancers; the change of E2 level can be used as a reference index for surgical indications and prognosis, and provides a certain theory for the possibility of sex hormone therapy for esophageal cancer. in accordance with.