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目的检测骨肉瘤中MMP-9的表达,探讨其在骨肉瘤发生、发展及转移中的作用。方法应用免疫组织化学技术检测46例骨肉瘤标本中MMP-9的表达。结果MMP-9在骨肉瘤组织中的表达量明显高于良性骨肿瘤组织,在有无软组织浸润及不同Ennecking分期的骨肉瘤之间比较,MMP-9表达差异有统计学意义(P<0.05)。结论骨肉瘤组织中MMP-9高表达,MMP-9在骨肉瘤发展中起重要作用。
Objective To detect the expression of MMP-9 in osteosarcoma and to explore its role in the occurrence, development and metastasis of osteosarcoma. Methods The expression of MMP-9 in 46 osteosarcoma specimens was detected by immunohistochemistry. Results The expression of MMP-9 in osteosarcoma was significantly higher than that in benign bone tumor. There was significant difference in MMP-9 expression between osteosarcoma with and without soft tissue infiltration and different Ennecking staging (P <0.05) . Conclusion The expression of MMP-9 in osteosarcoma tissue is high, and MMP-9 plays an important role in the development of osteosarcoma.