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目的总结系统性红斑狼疮(SLE)患者伴周围神经病的临床特征。方法回顾性分析16例SLE伴周围神经病的患者的临床资料。结果 16例患者中,对称性多神经病8例,多发性单神经病4例,单神经病1例,颅神经病变1例,自主神经病变2例。其中,四肢末端麻木9例,刺痛3例,烧灼样痛1例,痛觉过敏3例,肢体远端感觉减退9例,深感觉下降4例,肢体无力11例,足或腕下垂6例,肌肉萎缩3例,跟、膝腱反射减弱或消失5例。8例周围神经病患者同时合并有中枢神经系统受累。结论 SLE合并周围神经病感觉、运动常同时受累,可同时合并中枢神经系统病变。电生理检查可作为周围神经损害的早期诊断手段。
Objective To summarize the clinical features of peripheral neuropathy in patients with systemic lupus erythematosus (SLE). Methods The clinical data of 16 patients with SLE with peripheral neuropathy were analyzed retrospectively. Results Among the 16 patients, there were 8 cases of symmetrical polyneuropathy, 4 cases of multiple mononeuropathy, 1 case of mononeuropathy, 1 case of cranial neuropathy and 2 cases of autonomic neuropathy. Among them, the extremities end numbness in 9 cases, tingling in 3 cases, burning pain in 1 case, hyperalgesia in 3 cases, distal limb sensory decline in 9 cases, 4 cases of deep sensory decline, limb weakness in 11 cases, foot or wrist drooping in 6 cases, Muscle atrophy in 3 cases, with, knee tendon reflexes disappeared or disappeared in 5 cases. Eight patients with peripheral neuropathy also had central nervous system involvement. Conclusion SLE complicated by peripheral neuropathy sensory, exercise often involved, can be combined with central nervous system lesions. Electrophysiological examination can be used as an early diagnosis of peripheral nerve damage.