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检测了24例使用常规量庆大霉素（GM）1周患儿的血Tamm-Horsfall蛋白（THP）、尿素氮、肌肝及尿β_2-微球蛋白,同时设定对照组。结果GM组血THP为320.7±77.4ng/ml,显著高于对照组242.9±75.6ng/ml（P<0.05）,其异常增高率为62.5％,显著高于血尿素氮、肌酐异常增高率。两组血尿素氮、肌肝无显著性差异。血THP与尿β_2-MG间呈正的直线相关。提示血THP是一个敏感的早期诊断GM肾毒性的指标,可与尿β_2-MG结合来综合判断GM肾毒性中肾远端、近端小管的损伤,本文还分析了GM肾毒性致血THP升高的可能原因。
Twenty-four infants with normal gentamicin (GM) for one week were tested for serum Tamm-Horsfall protein (THP), urea nitrogen, muscle and urine β_2-microglobulin, and the control group was also set. Results The blood THP in GM group was 320.7 ± 77.4ng / ml, which was significantly higher than that in control group (242.9 ± 75.6ng / ml, P <0.05). The abnormal increase rate was 62.5%, which was significantly higher than that of blood urea nitrogen and creatinine. Blood urea nitrogen, muscle liver no significant difference. Blood THP and urinary β_2-MG showed a positive linear correlation. It is suggested that blood THP is a sensitive indicator of early diagnosis of GM nephrotoxicity and can be combined with urinary β_2-MG to determine the damage of distal and proximal renal tubules in GM nephrotoxicity. In addition, High possible reason.