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目的了解药品不良反应发生的特点及规律,促进临床合理用药。方法对抚顺市第五医院2007～2008年度收集的29例药品不良反应报告采用回顾性调查方法,按患者性别、年龄、给药途径、临床表现、药品种类等进行统计分析。结果29例药品不良反应主要与用法用量、合并用药、患者年龄有关,最常见表现为肝功能异常。结论研究组应用氯氮平联合利培酮治疗较对照组单用氯氮平治疗起效快,疗效更显著,大部分患者的攻击行为会随着精神症状的缓解而消失,且联合用药并未加重不良反应(P>0.05);如果必须即刻停氯氮平,建议患者住院,预防胆碱能反跳症状;应加强对医疗工作人员的业务素质培养,选择更佳的药物联合治疗方案,促进合理用药。
Objective To understand the characteristics and laws of adverse drug reactions and to promote rational clinical use. Methods A retrospective survey was conducted on 29 adverse drug reactions reported in the Fifth Hospital of Fushun City from 2007 to 2008. The data were analyzed according to patient’s sex, age, route of administration, clinical manifestation and type of drug. Results The adverse drug reaction in 29 cases was mainly related to dosage, combination medication and patient’s age. The most common manifestation was liver dysfunction. Conclusion The study group clozapine combined with risperidone than the control group alone clozapine treatment onset faster, the effect is more significant, most patients with aggressive behavior will disappear with the relief of mental symptoms, and the combination did not (P> 0.05). If clozapine should be stopped immediately, it is suggested that patients should be hospitalized to prevent symptoms of cholinergic reflex. Training should be strengthened on the professional quality of medical staff, better drug combination therapy and promotion Rational use of medicine.