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目的探讨新生儿机械通气相关性肺炎(VAP)的发病因素。方法对64例机械通气患儿下呼吸道分泌物进行培养及药敏试验,且对并VAP的感染率胎龄、体质量、机械通气持续时间等因素的关系进行分析。结果发生VAP 39例,发生率为60.94%。其主要病原菌为革兰阴性杆菌,占89.13%,以铜绿假单胞菌、肺炎克雷白杆菌、大肠埃希菌、鲍曼不动杆菌为多见。结论VAP感染率与机械通气持续时间有关。合理应用机械通气,及早撤机,合理应用抗生素,能有效预防和治疗VAP。
Objective To investigate the pathogenesis of neonatal mechanical ventilation-related pneumonia (VAP). Methods Sixty - four children with mechanical ventilation were selected to study the culture of lower respiratory secretions and drug susceptibility test. The relationship between VAP infection rate such as gestational age, body weight, duration of mechanical ventilation and other factors was also analyzed. Results VAP occurred in 39 cases, the incidence was 60.94%. The main pathogen of Gram-negative bacilli, accounting for 89.13%, with Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumanii more common. Conclusions VAP infection rate is related to the duration of mechanical ventilation. Rational use of mechanical ventilation, early weaning, rational use of antibiotics, can effectively prevent and treat VAP.