论文部分内容阅读
目的了解新疆维吾尔族女性HPV感染及其分布特征,为今后宫颈癌防治提供策略。方法采用横断面研究,于2006年在新疆于田县以整群抽样的方法选择年龄16～59岁、有性生活的维吾尔族女性约1000人行宫颈癌危险因素问卷调查和宫颈脱落细胞HPV DNA检测。所有女性均按年龄分层入组,先由调查员进行一对一的问卷调查,后由医师进行宫颈脱落细胞采样。将收集到的样本采用第2代杂交捕获(hc 2)试验进行HPV DNA检测。样本中检出的HPV DNA≥1.0 pg/mL即为感染阳性。结果共纳入883名新疆维吾尔族女性,平均年龄为36.26±10.10岁。其高危型HPV和低危型HPV感染率分别为7.25%和1.59%,总体HPV感染率为8.27%,明显低于中国汉族女性(16.1%)。HPV感染率在有2个以上性伴侣的女性中明显较高(x~2=5.254,P=0.022),但是在以下人群中无统计学差异:不同的年龄、教育和收入水平、初次性生活年龄及丈夫婚前、婚后有或无其他性伴侣。结论新疆维吾尔族女性HPV感染率明显低于中国汉族女性。其HPV感染可能与种族有一定关系,并受到性行为因素的影响。
Objective To understand the prevalence and distribution of HPV infection among Uighur women in Xinjiang and to provide strategies for future prevention and treatment of cervical cancer. Methods A cross-sectional study was conducted. In 2006, a cluster sampling method was used in Yutian County of Xinjiang to select a survey of risk factors for cervical cancer and HPV DNA in cervical exfoliated cells among 16 to 59-year-old Uighur women with sexual life . All women were stratified into groups by age, one by one by the investigators conducted a questionnaire survey, followed by a sample of cervical exfoliated cells by a physician. The collected samples were tested for HPV DNA using the second generation hybridization capture (hc 2) assay. HPV DNA ≥ 1.0 pg / mL detected in the sample is positive for infection. Results A total of 883 Uighur women were enrolled in Xinjiang, with an average age of 36.26 ± 10.10 years. The infection rates of high-risk HPV and low-risk HPV were 7.25% and 1.59%, respectively. The overall HPV infection rate was 8.27%, significantly lower than that of Chinese Han women (16.1%). HPV infection rates were significantly higher among women with more than 2 sexual partners (x 2 = 5.254, P = 0.022), but not statistically significant among different age groups, education and income levels, first-time sex Age and husband Before marriage, after marriage with or without other sexual partners. Conclusion HPV infection rates among Uighur women in Xinjiang are significantly lower than those in Han Chinese women. The HPV infection may have a certain relationship with the race, and by sexual factors.