噻吗洛尔timolol(噻吗心安)滴眼液是最早用于治疗青光眼的β-受体阻滞剂。有关该药的全身不良反应文献已有报道,笔者最近遇到1例滴眼致死病例,现报告如下。患者男,64a。原有慢性喘息性支气管炎及肺气肿病史7a。无药物过敏史。平素BP16.0/10.7kPa,ECG:窦性心律,心率62次/min,无传导阻滞。1990年5月22日因双眼视物模糊去某医院眼科就医,经检查诊断为右眼闭角型青光眼。给予0.5％噻吗洛尔滴眼液(天津市中兴制药厂,批号:890815),每日2次,每次1滴。患者翌日晨于右眼自点该药1滴,约20min后自觉胸闷、呼吸困难。其 Timolol timolol (timolol) eye drops is the earliest β-blocker for the treatment of glaucoma. The drug has been reported in systemic adverse drug reactions, the author recently encountered a case of eye death, are as follows. Patient male, 64a. The original history of chronic asthmatic bronchitis and emphysema 7a. No history of drug allergy. Normal BP16.0 / 10.7kPa, ECG: sinus rhythm, heart rate 62 beats / min, no conduction block. May 22, 1990 due to blurred vision binocular hospital ophthalmology, diagnosed as right angle closed-angle glaucoma. Give 0.5% timolol eye drops (Tianjin Zhongxing Pharmaceutical Factory, batch number: 890815), 2 times a day, each drop of 1. Patients in the right eye next morning since the drug 1 drop, conscious chest tightness after about 20min, difficulty breathing. its