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目的探讨血清α1微球蛋白、胎儿血红蛋白对子痫前期发病的预测价值。方法选取2013年10月-2015年2月在医院立卡产检的无妊娠合并症、并发症的单胎初产妇346例作为研究对象,其中正常对照组239例,妊娠期高血压组40例,轻度子痫前期组38例及重度子痫前期组29例。对所有产妇进行血清α1微球蛋白、胎儿血红蛋白检测,观察4组产妇的检测结果。结果正常对照组及妊娠期高血压组产妇的血清α1微球蛋白水平及胎儿血红蛋白水平(Hb F%)相比差异无统计学意义(P>0.05);轻度子痫前期组及重度子痫前期组产妇的血清α1微球蛋白水平及胎儿Hb F%较妊娠期高血压组显著提高,差异有统计学意义(P<0.05);与轻度子痫前期组相比,重度子痫前期组产妇的血清α1微球蛋白水平及胎儿Hb F%显著提高,差异有统计学意义(P<0.05)。4组产妇妊娠22~26周时的子宫动脉(左、右)RI值、胎儿的大脑中动脉RI、胎儿脐血流S/D值、早产率及阿氏评分差异均有统计学意义(P<0.05)。结论血清α1微球蛋白、胎儿血红蛋白对子痫前期发病具有重要预测价值,值得深入研究。
Objective To investigate the predictive value of serum α1 microglobulin and fetal hemoglobin in the pathogenesis of preeclampsia. Methods A total of 346 singleton primiparous women with pregnancy-related complications and complications in Rika check-up from October 2013 to February 2015 in our hospital were selected as the study subjects. Among them, 239 cases were normal control group, 40 cases were hypertensive pregnancy group, 38 cases of mild preeclampsia group and 29 cases of severe preeclampsia group. All maternal serum α1 microglobulin, fetal hemoglobin test, the results observed in 4 groups of maternal test. Results There was no significant difference in serum α1 microglobulin level and fetal hemoglobin level (Hb F%) between normal control group and gestational hypertension group (P> 0.05); mild preeclampsia group and severe eclampsia Compared with mild preeclampsia group, serum α1 microglobulin level and fetal Hb F% in preterm group were significantly higher than those in gestational hypertension group (P <0.05). Compared with mild preeclampsia group, severe preeclampsia group Maternal serum α1 microglobulin levels and fetal Hb F% increased significantly, the difference was statistically significant (P <0.05). The RI values of uterine artery (left and right), RI of fetal middle cerebral artery, fetal umbilical blood flow S / D, preterm birth rate and Ah’s score in 4 groups at 22-26 weeks’ gestation were significantly different (P <0.05). Conclusions Serum α1 microglobulin and fetal hemoglobin have important predictive value for the pathogenesis of preeclampsia and deserve further study.