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目的 探讨柯萨奇 Ｂ 组病毒（ Ｃ Ｖ Ｂ） 感染与哮喘发作的关系。方法 观察急性发作期哮喘患儿１０２ 例、上呼吸道感染１８２ 例、非感染性疾病患儿７１ 例、健康儿童３０ 例。采用 Ｅ Ｌ Ｉ Ｓ Ａ 法测定静脉血 Ｃ Ｖ Ｂ 抗原（ Ｃ Ｖ Ｂ－ Ａｇ）和 Ｉｇ Ｍ 抗体（ Ｃ Ｖ Ｂ－ Ｉｇ Ｍ） 、免疫组化法测定 Ｔ 细胞亚群和［３ Ｈ］ － Ｔｄ Ｒ 标记法测定 Ｎ Ｋ 细胞活性。结果 ①哮喘患儿 Ｃ Ｖ Ｂ 感染率为５７８ ％ （５９／１０２） ；②哮喘患儿 Ｃ Ｄ８ 显著升高； Ｃ Ｄ３ 、 Ｃ Ｄ４／ Ｃ Ｄ８ 及 Ｎ Ｋ 细胞活性均明显下降（ Ｐ ＜００１） ；而 Ｃ Ｖ Ｂ 阳性哮喘患儿 Ｎ Ｋ 细胞活性又低于非 Ｃ Ｖ Ｂ 阳性哮喘儿（ Ｐ ＜ ００５） ， Ｃ Ｄ８ 明显高于非 Ｃ Ｖ Ｂ 阳性哮喘儿（ Ｐ ＜ ００１） 。结论 Ｃ Ｖ Ｂ 感染与哮喘发作有密切关系。
Objective To investigate the relationship between Coxsackie B virus (C V B) infection and asthma attack. Methods 102 cases of asthma, 182 cases of upper respiratory tract infection, 71 cases of non-infectious disease and 30 healthy children were observed during the acute episode. The venous blood VV B antigen (C V B-Ag) and Ig M antibody (C V B-Ig M) were measured by E L I S A method. The T cell subsets and [3 H] -Td R-labeled N K cell activity was measured. Results ① The prevalence of C V B in children with asthma was 578% (59/102). ② The levels of C D8 in children with asthma were significantly increased, and the activities of C D3, C D4 / C D8 and N K were significantly decreased (P < 0 01). However, the activity of N-killer cells in children with C V B-positive asthma was lower than those without C V B (P <005), and C D8 was significantly higher than those without C V B-positive asthma (P < 0 01). Conclusion C V B infection is closely related to asthma attack.