论文部分内容阅读
目的:评价血浆心脏特异性肌钙蛋白I(cardiactroponinI,cTnI)和血栓前体蛋白(thrombusprecursorprotein,TPP)水平测定对不同程度心功能障碍患者心肌损伤的诊断价值。方法:分别测定入院12小时内的136例不同程度心功能障碍患者(患者组)及20名健康人(对照组)的cTnI、TPP和肌酸激酶(creatinekinase,CK)同工酶(MB)水平,并作分析比较。结果:患者组cTnI、TPP和CK-MB水平均高于对照组(均为P<0.05),心功能Ⅳ级组患者的cTnI、TPP和CK-MB水平高于心功能Ⅲ级组,而心功能Ⅲ级组又高于心功能Ⅱ级组。同时136例心功能障碍患者中有95例cTnI阳性,占69.9%;98例TPP阳性,占72.1%;31例CK-MB阳性,占22.8%。直线相关分析显示,心功能障碍患者体内的cT-nI水平与TPP水平呈正相关(r=0.52,P<0.05)。结论:cTnI、TPP是反映心肌损伤的灵敏性较高的生化指标,两者水平增高可作为判断心肌损伤程度的辅助指标。
Objective: To evaluate the diagnostic value of plasma cardiac-specific cardiac troponin I (cTnI) and thrombusprecursorprotein (TPP) levels in the diagnosis of myocardial injury in patients with different degrees of cardiac dysfunction. Methods: The levels of cTnI, TPP and creatine kinase (CK) isoenzymes (MB) were determined in 136 patients with different degrees of cardiac dysfunction (patient group) and 20 healthy persons (control group) within 12 hours after admission , And make analysis and comparison. Results: The levels of cTnI, TPP and CK-MB in the patients were higher than those in the control group (all P <0.05). The levels of cTnI, TPP and CK-MB in patients with grade IV cardiac function were higher than those in patients with grade Ⅲ cardiac function, Function Ⅲ level group was higher than heart function Ⅱ level group. At the same time, 95 out of 136 patients with cardiac dysfunction had cTnI positive, accounting for 69.9%; 98 TPP positive, accounting for 72.1%; 31 CK-MB positive, accounting for 22.8%. Linear correlation analysis showed that the level of cT-nI in patients with cardiac dysfunction was positively correlated with the level of TPP (r = 0.52, P <0.05). Conclusions: cTnI and TPP are the biochemical indicators that reflect the high sensitivity of myocardial injury. Both of them may serve as auxiliary indicators for judging the degree of myocardial injury.