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目的:探讨慢性愤怒应激对大鼠衰老进程的影响及其神经内分泌免疫机制。方法:在D-半乳糖(D-gal)衰老及脑老化模型基础上引入愤怒刺激,观察慢性愤怒应激对大鼠空间学习记忆能力的影响;测定脑组织及血清去甲肾上腺素(NE)、五羟色胺(5-HT)含量、血清皮质酮(CORT)水平以及脾脏指数。结果:与D-gal组比较,愤怒D-gal大鼠空间学习记忆能力下降;脑组织和血清NE升高、5-HT降低;血清CORT水平升高;脾脏指数下降。结论:慢性愤怒应激加重D-gal大鼠的衰老及脑老化程度,加速衰老进程。HPA轴和SAS持续兴奋,神经内分泌紊乱和免疫功能抑制是其可能的机制。
Objective: To investigate the effect of chronic anger stress on the aging process and its neuroendocrine mechanism. Methods: Anger stimulation was introduced on the basis of D-galactose (D-gal) senescence and aging model to observe the effects of chronic anger stress on spatial learning and memory in rats. The levels of norepinephrine (NE) , Serotonin (5-HT) content, serum corticosterone (CORT) level and spleen index. Results: Compared with D-gal group, the spatial learning and memory abilities of Angry D-gal rats were decreased. The levels of NE and NE in brain and serum were decreased, while the levels of serum 5-HT and CORT were decreased. Conclusion: Chronic anger stress aggravates the aging and brain aging of D-gal rats and accelerates the aging process. Continued excitement of the HPA axis and SAS, neuroendocrine disorders and immune suppression are their possible mechanisms.