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灌胃酒石酸锗复合物20mg·kg-1,明显地抑制二甲苯或巴豆油所致小鼠耳壳肿胀,抑制角叉菜所致大鼠足肿胀,抑制小鼠棉球肉芽肿增生及佛氏完全佐剂所致大鼠关节炎.这表明,酒石酸锗夏合物具有抑制急、慢性及免疫性炎症的作用,还降低小鼠毛细血管通透性,增强小鼠单核巨噬细胞系统的吞噬功能,抑制大鼠热烫足肿胀,减少大鼠炎症部位的PCE2含量.提示,酒石酸锗复合物的抗炎作用与降低毛细血管通透性,增强单核巨噬细胞的吞噬功能和抑制炎症部位的激肽类、PGE2的合成、释放有关.
Administration of germanium tartrate 20 mg · kg-1 significantly inhibited swelling of the mouse ears caused by xylene or croton oil, inhibited carrageenan-induced foot swelling and inhibited the growth of cotton granuloma in mice Complete adjuvant-induced arthritis in rats. This shows that the Germanium tartrate Xiaji role in inhibiting acute, chronic and immune inflammation, but also reduce capillary permeability in mice and enhance the phagocytosis of mouse monocyte-macrophage system, inhibition of heat-induced foot swelling in rats , Reduce the inflammatory content of PCE2 in rats. It is suggested that the anti-inflammatory effect of the germanium tartrate complex is related to the reduction of capillary permeability, the phagocytic function of monocyte-macrophage cells and the suppression of the inflammatory peptides kinins, PGE2 synthesis and release.