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肝病对人类的危害日益猖獗,我国尤甚,占40岁以上年龄组总死亡数第4～5位。肝性脑病是各种严重肝病的并发症或终末表现,将近20年来对其发病机理已有逐渐深入的了解,除人们熟知的氨毒学说外,Fischer首创的假神经递质理论近年来又发展为血浆氨基酸失衡学说作为其进展和补充。大量资料表明,肝病时肝机能不全特别伴门体静脉分流时,大都有血浆氨基酸谱的改变,表现为苯丙氨酸、酪氨酸和色氨酸3种芳香族氨基酸(AAA)
The harm of liver diseases to human beings is increasingly rampant, especially in China, accounting for the fourth to fifth of the total deaths in the age group over 40 years old. Hepatic encephalopathy is a complication or terminal manifestation of various severe liver diseases. For nearly 20 years, the pathogenesis of hepatic encephalopathy has been gradually in-depth understanding. In addition to the known ammonia toxicity theory, Fischer’s first theory of pseudo-neurotransmitter in recent years Development of the theory of plasma amino acid imbalance as its progress and complement. A large number of data show that liver disease liver insufficiency with portal vein shunt, most of the changes in plasma amino acid profile, the performance of phenylalanine, tyrosine and tryptophan three kinds of aromatic amino acids (AAA)