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目的:中药复方配合非布司他片治疗痛风性肾病临床疗效的影响。方法:回顾性研究我院痛风性肾病患者90例,应用随机数字表法将所有患者随机分为对照组和实验组,对照组应用非布司他片进行治疗,实验组在对照组的治疗基础上应用我院制剂加味玉肾露。随诊观察3个月,比较治疗前后两组患者血尿酸(UA)、血清肌酐(SCR)、血尿素氮(BUN)、尿β_2-微球蛋白(β_2-MG)、血清总胆固醇(TC)、甘油三酯(TG)及高密度脂蛋白(HDL)水平变化,并对两组患者的临床疗效进行对比分析。结果:与对照组相比,实验组患者UA、SCR、BUN、β_2-MG、TC及TG水平较低(P<0.05);HDL水平较高(P<0.05)。结论:在非布司他片的治疗基础上联合使用加味玉肾露能够调节痛风性肾病的血脂,保护肾脏,可以在临床上推广使用。
Objective: The effect of compound traditional Chinese medicine and febuxostat in the treatment of gouty nephropathy. Methods: A retrospective study of 90 patients with gouty nephropathy in our hospital, all patients were randomly divided into control group and experimental group using random number table method, the control group treated with non-bubusate tablets, the experimental group in the control group based on the treatment Application of our hospital flavored jashen Lu. The levels of serum uric acid (UA), serum creatinine (BUN), urinary β_2-microglobulin (β_2-MG) and serum total cholesterol (TC) were compared between the two groups before and after treatment. , Triglyceride (TG) and high-density lipoprotein (HDL) levels were analyzed. The clinical efficacy of the two groups were compared. Results: Compared with the control group, the levels of UA, SCR, BUN, β 2-MG, TC and TG in the experimental group were lower (P <0.05) and HDL levels were higher (P <0.05). Conclusion: Based on the treatment of febuxostat, the combined use of jasmine dextrin can regulate the blood lipid of gouty nephropathy and protect the kidneys, which can be widely used clinically.